integrated-lp

Board-Certified Emergency Physician

Editor, Emergency Medicine News

GWU Research Collaborator

Former State Chief Physician

Former White House Task Force Advisor

National KOL

He called it allithiamine — a lipid-soluble derivative of thiamine (vitamin B1) that could cross cell membranes without relying on saturable transporters. Unlike standard thiamine hydrochloride, which gets blocked at the gut wall and excreted rapidly, allithiamine penetrates tissue directly.

Once inside the cell, allithiamine is trapped and converted to active thiamine pyrophosphate — the cofactor required for mitochondrial energy production and neurotransmitter synthesis. This makes it uniquely suited for reaching metabolically active tissues like the enteric nervous system.

The enteric nervous system — often called the 'second brain' — contains more neurons than the spinal cord and regulates motility, secretion, and visceral sensation. When thiamine-dependent enzymes are undersupplied, enteric signaling becomes dysregulated, leading to upper GI symptoms and lower GI urgency.

By delivering thiamine in a form that bypasses transporter bottlenecks, allithiamine supports enteric neuron function at the cellular level — addressing the metabolic root of post-meal distress rather than masking symptoms.

And the second hero: Chios mastic gum.

Harvested from Pistacia lentiscus trees on the Greek island of Chios, mastic gum has been used for centuries to support digestive health. Modern research shows it helps modulate gastric mucosa, supports microbial balance, and may reduce upper GI discomfort — making it an ideal companion to allithiamine's neurometabolic support.

How allithiamine reaches your enteric nervous system.

Crosses membranes directly. Trapped intracellularly. Reaches enteric neurons.

Allithiamine from garlic

Lipid-Soluble Allithiamine

Blocked by saturable transporter. Excreted rapidly. Poor tissue penetration.

Standard thiamine HCl

Water-Soluble B1

In 2026, Gut, the world's most prestigious GI journal, published the largest genetic study ever done on bowel motility. The result: vitamin B1 metabolism is a causal pathway. Not a correlation. A cause.

Díaz-Muñoz et al. (2026), Gut. PMID 41558814. n=268,606.

In 1951, a Japanese chemist named Fujiwara isolated something unusual from garlic.

Lipid-soluble B1, enteric nerve repair, double the Clear dose.

HERO INGREDIENT

150mg

Allithiamine

Upper GI, functional dyspepsia.

HERO INGREDIENT

500mg

Chios Mastic Gum

Prokinetic, anti-nausea.

100mg

Ginger Root 4:1

Mucosal soothing, IBS-D evidence.

100mg

Aloe Vera Inner Gel 200:1

Gastric mucosal support.

80mg

DGL Licorice

Tight junction integrity, gastric lining.

5mg

Zinc L-Carnosine

Smooth muscle calm.

100mg

Magnesium Glycinate

Every ingredient, with context.

What does the 365-day guarantee cover?

The science, with citations.

2 Bottles — 60-Day Protocol

60 Days

~~US$139.98~~

US$118.98

Save $21 with code 60DAY

$1.98/day

The full clinical protocol

Choose your protocol

Not all solutions are created equal.

Property

Loperamide

Dicyclomine

MGB+ Cool

Targets the cause

Yes

Works on upper GI

Partial

Yes

Works on lower GI urgency

Yes

Drowsiness / dry mouth

Yes

Reaches enteric nerves

Yes (allithiamine)

Long-term use safe

Limited

Yes

Prescription required

Yes

Take two capsules nightly with food.

2) Week 2: Cellular uptake begins

Allithiamine crosses cell membranes. Enteric neurons begin receiving B1 at therapeutic levels.

3) Week 3: Mitochondrial activation

B1-dependent enzymes restore energy production. Early responders notice reduced post-meal urgency.

4) Week 4: Neurotransmitter normalization

Acetylcholine synthesis improves. Gastric motility and upper GI distress begin stabilizing.

5) Week 5: Vagal tone retraining

Enteric nervous system signaling becomes more regulated. Bloating and nausea decrease noticeably.

6) Week 6: Tissue repletion deepens

B1 stores reach therapeutic saturation. Gut-brain signaling becomes more consistent meal-to-meal.

7) Week 7: Full neurometabolic support

Enteric nerves sustain optimal function. Most users report stable digestion without post-meal distress.

8) Week 8: Sustained resilience

The full protocol is complete. Your enteric nervous system is optimally supported for long-term digestive health.

1) Week 1: Initial coating

Take 2 capsules with your largest meal. Mastic gum starts coating the upper GI lining.

Your 60-day protocol, week by week.

Your enteric nervous system has 500 million neurons. B1 tissue repletion takes 6 to 8 weeks even at therapeutic doses. Vagal tone retraining is a slow process. Thirty days catches the early responders but misses the patients whose nerves need longer to rebuild.

Tissue repletion

B1-dependent enzymes begin restoring mitochondrial function and neurotransmitter synthesis.

Weeks 3–4

Vagal tone retraining

Enteric nervous system signaling normalizes, reducing post-meal distress and urgency.

Weeks 5–8

Cellular saturation

Allithiamine begins crossing the gut epithelium and reaching enteric neurons.

Weeks 1–2

The 60-Day Protocol exists because 30 days isn't enough time for your gut to heal.

Two bottles. One protocol. Save 15% with code 60DAY.

Why 60 days is the minimum dose of time.

You've cut out gluten. You've cut out dairy. You've tried digestive enzymes, probiotics, and three different acid blockers. Your gastroenterologist scoped you and said everything looks fine. It's not in your head. It's the post-meal phenotype — upper GI distress and lower GI urgency riding the same broken signal between your gut and your brain.

You've tried everything. Your tests still come back normal.

You'll benefit if...

You have post-meal bloating and pressure

You experience urgency within 30-60 minutes of eating

You have alternating IBS-D and upper GI distress

Your endoscopy was normal but symptoms persist

You've cycled through acid blockers and antispasmodics

This isn't right if...

You have classic GERD with esophagitis

You have IBD in active flare

You have active H. pylori (treat first)

You're pregnant or breastfeeding

Collapsible Title

Frequently asked questions

A note from Dr. Rick

I built MGB+ Cool for the patient I see every shift who tells me 'I can't eat anywhere without knowing where the bathroom is.' Their workup is normal. Their life is not. Mastic gum has 2,500 years of use and a real RCT in functional dyspepsia. Allithiamine reaches the nerves that standard B1 can't. Together, they target the post-meal phenotype directly. Give it 60 days.

— Rick Pescatore, D.O., Board-Certified Emergency Physician, National Gut-Brain Expert, and Public Health Leader

What people are saying after they tried it.

Save 15% with code 60DAY at checkout.

Start your 60-Day Protocol.

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Refund Policy

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Take the full 60-Day Protocol. If it doesn't work, ship the empty bottles back. Zero risk. No questions asked.

365-Day Money-Back Guarantee

Patient reviews

'After eight weeks on the protocol, my gut finally feels predictable again. I wish I had found this two years ago.'

— Sarah M.

'I was skeptical of another supplement, but the science behind allithiamine convinced me to try the 60-day protocol. Week 5 was when things clicked.'

— James T.

'My gastroenterologist couldn't figure out why my tests were normal but I felt terrible. MGB+ Cool was the missing piece.'

— Linda K.

'The physician voice on this page is what sold me. No hype, just mechanism. It works.'

— Michael R.

'I've been on PPIs for ten years. Within six weeks of starting MGB+ Cool, my motility issues improved dramatically.'

— Patricia D.

'The 60-day protocol makes sense. I tried a 30-day B1 supplement before and gave up. This time I committed to the full eight weeks and saw real results.'

— David L.

You eat. Thirty minutes later, you're in the bathroom. Or nauseous. Or both.

MGB+ Cool pairs 500mg of Chios mastic gum with 150mg of allithiamine — the lipid-soluble B1 that reaches the enteric nerves controlling your upper GI and your urgency.

(Based on patient feedback)

cGMP Certified

3rd-Party Tested

Made in USA