Start here if meals leave your upper gut hot, heavy, unsettled, or hard to move past.
Start here if meals leave your upper gut hot, heavy, unsettled, or hard to move past.
Tell Dr. Rick what your gut feels like and he picks your starting formula before it ships.
Gut-brain symptoms often involve signaling, motility, sensitivity, and cellular energy. MGB+ starts with lipid-soluble B1 and magnesium glycinate, then adds formula-specific actives based on the symptom pattern.
This page is focused on upper-gut burn, post-meal heaviness, and meal tolerance.
See every ingredient and dose →Individual experiences. Results vary. Reviews are useful for pattern recognition, not guaranteed outcomes.
Cant tell you how much I missed Indian food. Cool has me eating it again. Genuine joy. I take it with breakfast specifically because thats when my reflux used to be worst. Within 2 hours of the dose Im noticeably better even on bad days. I want to share more because the off-PPI experience matters. My GI had...
Been on the product for a little over a week. No change so far.
Took 5 weeks to fully kick in. I almost gave up at week 3. Glad I didnt.
GF for 6 years and the gut healed mostly but the reflux never fully resolved. Cool closed the gap. Six weeks. My partner started taking it too after seeing my results. Hes off his daily Pepcid as well now. Family wins and we save money on antacids.
I had a wedge pillow, an under-mattress wedge, and I was still waking up burning. Cool changed that in about 3 weeks. The wedge is in the garage. I keep the bottle on my desk at work. The 230pm reflux that used to hit after lunch doesnt show up anymore. Cant believe its this simple.
BellyMD is built to feel different from ordinary supplement brands: open formula, clinical discipline, manufacturing transparency, and careful educational framing.
BellyMD has entered into a research option agreement with a major U.S. research university around blood biomarkers and diagnostic methods for cannabinoid hyperemesis syndrome. The agreement gives BellyMD an option to negotiate an exclusive license in the field of use.
Our educational framework is informed by Rome Foundation diagnostic concepts and ACG/AGA guidance on disorders of gut-brain interaction. BellyMD supplements are not diagnostic tools and are not intended to treat disease.
Rick serves on the G-PACT Board of Advisors. BellyMD also supports GI patient advocacy initiatives, including Crohn's & Colitis community efforts, and Rick serves on the End Overdose board.
Mastic gum from a Mediterranean tree. Zinc-carnosine, a prescription ulcer drug in Japan. Most US consumer products skip both.
Real customer messages, in their own words. Pattern signals from people running Cool against the upper-GI cluster.
Klaviyo customer survey, n=204, May 2026. Self-reported repurchase intent at 8 weeks.
Acid is one part of the story. There's also the lining, the muscle and nerves that move food along, the immune signal that can drive reflux, and the bacteria many of us carry that quietly inflame the stomach. Cool was built for the other four.
Mastic gum and zinc-carnosine. A lot of adults carry a stomach bug called H. pylori without knowing. It quietly drives gastritis and many ulcers. These two ingredients have decades of clinical evidence in this exact role.
Aloe inner gel (200:1 concentrate) and DGL licorice. The protective mucus layer over your stomach gets thinned by acid blockers, alcohol, and stress. These two help your body restore it.
Ginger 4:1 extract and allithiamine. When food sits too long in the upper stomach, the burning and fullness get worse. Gentle motility support, no prescription needed.
Zinc-carnosine and mastic gum. The immune cells in your stomach wall release signals that drive reflux even when the acid is suppressed. These compounds calm that immune layer.
Magnesium glycinate and allithiamine. The brain side of the picture. Seven ingredients. Five mechanisms. Built to work alongside whatever else you're on, or on its own.
Mastic gum is a resin from a Mediterranean tree, used in Mediterranean medicine for thousands of years. Modern clinical trials show it helps the body manage H. pylori and improves the heavy-after-meal pattern. Most heartburn products skip it. It's expensive and slow to source. Cool uses 500 mg per dose, the range used in published trials.
Seven ingredients. No proprietary blends. Every dose disclosed. Every mechanism named.
Resin from the Pistacia lentiscus tree, used in Mediterranean medicine for thousands of years. Modern clinical trials show benefit for H. pylori and dyspepsia symptoms.
A fat-soluble form of vitamin B1 first found in garlic. Crosses cell walls and the blood-brain barrier where regular B1 cannot. Powers the energy your gut nerves need to keep food moving.
The form your nerves actually use. Magnesium bound to glycine. Absorbs well in the small intestine. None of the laxative effect of cheaper magnesium forms.
Prokinetic and antinausea action. The fastest-acting ingredient in the formula. The 4:1 extract concentrates the active compounds about four times stronger than regular ginger.
Concentrated aloe inner leaf gel. Coats and soothes the gastric lining. The 200:1 ratio means each 100 mg equals about 20 grams of fresh aloe gel.
Deglycyrrhizinated licorice. The glycyrrhizin has been removed so there's no blood pressure effect. Helps stimulate the protective mucus layer over the stomach lining.
Zinc bound to a small protein called carnosine. A prescription ulcer drug in Japan since 1994. Protects the stomach lining, helps manage H. pylori, and calms the immune signal that drives reflux.
Vegetable capsule · No artificial colors, sweeteners, or fillers · Third-party tested every batch
The stack most patients build for the heavy-after-meal pattern. Four products, three pharmacy runs, no strategy. Or one bottle of Cool.
About $39 a month not spent. One bottle, seven ingredients, four mechanisms.
DGBI rarely lives in one zone. The formulas are built to stack — and they share a single subscription cadence. Save 15% with any Duo, 20% with the Trio.
For the days the symptoms travel into your head. Brain fog, fatigue, headache. 15% off both bottles.
For sensitive stomachs and wired evenings. The morning side of the gut-brain axis. 15% off both bottles.
All three formulas. Save 30% vs three individual subscriptions.
Practicing physicians and researchers whose work shapes how gut-brain conditions get diagnosed, dosed, and treated.
Emergency physician and meta-researcher. His JAMA Internal Medicine work on low-quality systematic reviews shapes how clinicians evaluate the evidence behind supplement and gut-brain treatments.
Johns Hopkins School of Medicine
Emergency physician whose 2015 Annals trial established sub-dissociative ketamine in ED analgesia and reshaped how acute and chronic pain are managed at the bedside.
Maimonides Medical Center, Brooklyn
Army pediatric gastroenterologist. Built the Clinical Action Plans toolkit that brings structured, evidence-based GI care to pediatric populations across the Department of Defense.
Brooke Army Medical Center
Cool exists for what's underneath the acid. I see the same patient month after month. Scoped, biopsied, normal, sent home on another acid blocker that doesn't fix the lining, the motility, the immune signal, or the H. pylori bug they might be carrying. Acid blockers do what they do. Cool handles the rest.
The upper gut has more going on than acid. The lining. How fast it moves food. The immune signal. The H. pylori many patients still carry. Acid blockers aren't built for those.
I built Cool for those parts. To work alongside what your doctor has prescribed. The acid blocker handles the acid. Cool handles the rest.
Ginger acts the fastest. Many people notice less post-meal burn in the first week. The lining support layer (mastic, zinc-carnosine, aloe, DGL) is a slower build over four to twelve weeks. The bigger pattern changes (fewer reactive episodes, more predictable mornings) show up by week eight to twelve.
Yes. One click in your account. No retention call, no email gauntlet. Skip a month, swap formulas, or pause indefinitely. All from the same screen.
Twelve weeks. That's the window your gut needs to actually shift. If the pattern hasn't moved by then, email us within 90 days of your first order and we refund it in full. No bottle return required. We'd rather swap you to a different formula at no charge than refund. Most people who weren't a match for one formula are a match for another. Email us and we'll work it out.
Yes. Cool was built to work alongside prescription acid suppression, not to replace it. The acid blocker handles the acid. Cool supports the lining, the motility, and the immune signal. The parts most acid blockers don't address. If you're on a PPI long-term, talk to your physician about the strategy. We have no interest in interfering with your prescribed care.
Cool is not a treatment for active H. pylori infection. The standard of care is a course of antibiotics plus acid suppression prescribed by your physician (typically a triple or quadruple therapy). Mastic gum and zinc-carnosine have clinical evidence for supporting the body in managing H. pylori. They're widely used alongside the standard treatment in the literature. They are not a substitute for the proven curative protocol.
US cGMP facility. Third-party tested. Every ingredient and dose is disclosed on the bottle and the open-formula section above. We use the active form of each compound (allithiamine over thiamine HCl, zinc-carnosine over zinc gluconate, 4:1 ginger extract over powder).
