Functional Dyspepsia
Functional Dyspepsia
Burning, fullness, or pain in the upper stomach with normal-looking scopes. The forgotten DGBI.
Functional dyspepsia is a pattern of upper-belly trouble, where the stomach over-reacts to small meals and quiet acid. Scopes and ulcer tests are usually clean. Most people who get a real diagnosis and a real plan see meaningful relief in 4 to 8 weeks.
Functional dyspepsia (FD, ICD-10 K30) is a disorder of gut-brain interaction defined by bothersome upper-abdominal symptoms — postprandial fullness, early satiety, epigastric pain, or epigastric burning — present at least 3 days per week, with normal upper endoscopy. Rome V (2026) splits FD into two clinically distinct subtypes: postprandial distress syndrome (meal-induced) and epigastric pain syndrome (independent of meals). Adult prevalence is approximately 7% globally.
Patterns and subtypes
PDS
- Fullness after a small meal
- Early satiety
- Bloating after eating
- Big meals
- Fatty meals
- Eating too fast
EPS
- Burning or pain in the upper belly
- Worse on empty stomach
- Eases briefly with food
- Spicy foods
- Coffee
- NSAIDs (ibuprofen, aspirin)
Mixed
- Both fullness and burning
- Pattern shifts day to day
- Often overlaps with reflux
- Big meals + spicy
- Late dinners
- Sleep loss
What your doctor might miss
Red flags
- Black, tarry stools
- Vomiting blood
- Severe, sudden chest or upper belly pain
- Trouble swallowing that's getting worse
- Unintended weight loss
- New symptoms after age 60
- Iron-deficiency anemia
- Persistent vomiting
- Family history of stomach cancer
- Long NSAID or aspirin use
- Peptic ulcer — endoscopy distinguishes.
- H. pylori infection — stool antigen or breath test.
- Gallbladder disease — right-side pain, ultrasound.
- Gastroparesis — slow stomach emptying study.
