Start here if you recognize more than one pattern: bloating + fog, upper-gut heaviness, and queasy/nervous stomach days.
Gut-brain symptoms often involve signaling, motility, sensitivity, and cellular energy. MGB+ starts with lipid-soluble B1 and magnesium glycinate, then adds formula-specific actives based on the symptom pattern.
This page is focused on mixed gut-brain patterns that move between formulas.
See every ingredient and dose →BellyMD is built to feel different from ordinary supplement brands: open formula, clinical discipline, manufacturing transparency, and careful educational framing.
BellyMD has entered into a research option agreement with a major U.S. research university around blood biomarkers and diagnostic methods for cannabinoid hyperemesis syndrome. The agreement gives BellyMD an option to negotiate an exclusive license in the field of use.
Our educational framework is informed by Rome Foundation diagnostic concepts and ACG/AGA guidance on disorders of gut-brain interaction. BellyMD supplements are not diagnostic tools and are not intended to treat disease.
Rick serves on the G-PACT Board of Advisors. BellyMD also supports GI patient advocacy initiatives, including Crohn's & Colitis community efforts, and Rick serves on the End Overdose board.
Each Trio shipment contains one bottle each of Clear, Cool, and Calm. Three formulas covering the three sides of the gut-brain axis. Same 90-day cadence, bundle pricing.
For the days bloating, brain fog, fatigue, and headache all show up together. Allithiamine + magnesium glycinate + PEA + 5 helpers.
For reflux, post-meal heaviness, and mornings that start with the stomach turning. Mastic gum + allithiamine + zinc-carnosine + ginger + 3 helpers.
For queasy mornings, cyclical nausea, and the stomach that won't tolerate breakfast. Beta-caryophyllene + benfotiamine + ginger + magnesium glycinate + curcumin.
Trio · $104.99 every 90 days · saves $60 vs three individual bottles
No complicated schedule. No fixed order. Built to fit the way you already eat.
Not two of each. Two total — pulled from whichever formula matches what your day is doing.
With food makes them gentler on the stomach. Three capsules a day is the maximum.
The three formulas target different sides of the gut-brain axis. A bloating-and-brain-fog day might be 2 Clear. A heavy-meal evening might be 1 Cool. A queasy morning might be 1 Calm. A mixed day might be 1 of each.
Pay attention to what shifts. The Trio is built for flexibility, not a fixed schedule.
Some shifts come within days: brain fog, sleep quality, morning queasiness. The full gut-brain pattern shift takes the full window.
Track honestly. That's why our guarantee runs 12 weeks.
If you take prescription medications, are pregnant or nursing, or have a chronic medical condition, check with your doctor before starting any new supplement.
Self-reported outcomes from Trio customers. Three formulas working in concert.
Aggregated from a Klaviyo customer survey, n=204 respondents, May 2026. Self-reported, not a clinical trial.
Your gut and brain are in constant conversation. The vagus nerve, the enteric nervous system, and the gut microbiome signal up. The brain signals back down through hormones, inflammation, and stress chemistry. When that conversation runs smoothly, you feel clear, comfortable, and steady. When it doesn't, you get the pattern: bloating, brain fog, fatigue, queasy mornings, sleep that won't hold.
Each MGB+ formula targets a different layer of that conversation. Clear addresses the bloating-and-brain-fog cluster. Cool calms the upper-gut layer. Calm steadies the morning rhythm. The Trio works because the three layers reinforce each other.
The stack most patients build for the full gut-brain pattern. Six to ten products, three pharmacy runs, no strategy. Or one box of MGB+ Trio.
Three layers of the axis. One ship date. $35 saved vs subscribing to each individually.
Practicing physicians and researchers whose work shapes how gut-brain conditions get diagnosed, dosed, and treated.
Emergency physician and meta-researcher. His JAMA Internal Medicine work on low-quality systematic reviews shapes how clinicians evaluate the evidence behind supplement and gut-brain treatments.
Johns Hopkins School of Medicine
Emergency physician whose 2015 Annals trial established sub-dissociative ketamine in ED analgesia and reshaped how acute and chronic pain are managed at the bedside.
Maimonides Medical Center, Brooklyn
Army pediatric gastroenterologist. Built the Clinical Action Plans toolkit that brings structured, evidence-based GI care to pediatric populations across the Department of Defense.
Brooke Army Medical Center
I'm Rick Pescatore. ER doctor. Editor-in-chief of Emergency Medicine News. The emergency department is where I first saw the pattern. It's not where the pattern lives. Bloating. Brain fog. Fatigue that doesn't lift. The gut that runs the day. The labs come back normal. The scans come back normal. The medications never quite fit.
MGB+ is built around that pattern, not around the symptoms it produces. Three formulas. Real doses. Every ingredient on the label. It's the protocol I'd run on my own family. It's the protocol I run on myself.
Two capsules a day, total. Not two of each. The three formulas are designed to be mixed and matched — pull from whichever one matches what your gut is doing that day. With food is easier on the stomach. Maximum is three capsules a day.
Match the formula to the pattern. A bloating-and-brain-fog day might be 2 Clear. A heavy-meal evening might be 1 Cool. A queasy morning might be 1 Calm. A mixed day might be 1 of each. The Trio is built for flexibility, not a fixed schedule. Pay attention to what shifts after a few weeks and lean into the formula that's doing the most work for your pattern.
Generally yes. The Trio is built on well-studied molecules with strong safety profiles, and most customers stack it with other things they're already taking. If you take prescription medications, are pregnant or nursing, or have a chronic medical condition, check with your doctor before starting any new supplement.
After 8 to 12 weeks, you'll have a clearer sense of which formula is doing the most work for your specific pattern. You can stay on the full Trio, drop to two formulas, or shift to a single one. Your subscription is fully editable. Pause, swap, skip, or cancel anytime.
Some customers feel a shift within days, particularly with brain fog, sleep quality, and morning queasiness. The full pattern shift takes 8 to 12 weeks. That's why our guarantee runs 12 weeks. It's the realistic window for gut-brain conditions to remodel.
Every 90 days. One box of three bottles is a 90-day supply at the standard two-capsule-per-day dose, so the subscription ships in time to keep you covered without piling up surplus bottles. Single Trio is one box, one-time, no subscription. You can switch between subscription and one-time anytime, and you can pause, skip, swap, or cancel.
Yes. Every batch is tested by an independent laboratory for ingredient potency, heavy metals, and contaminants — not the same lab that makes the supplement. We use US cGMP facilities.
Twelve weeks is the realistic window for a gut-brain pattern to shift. If yours hasn't moved by then, email us within 90 days of your first order. We refund it in full. No bottle return required. If you'd rather swap formulas than refund, we'll do that too.
