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Gut-brain in plain English.

Research, mechanism, and small daily decisions. Written by an ER physician for the cluster of people the textbooks keep missing.

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Gut-Brain Basics

Does vitamin B1 help fatigue? One good trial, and one that failed to replicate

The short answer One good randomized trial found high-dose thiamine cut fatigue in people with quiescent inflammatory bowel disease (IBD). The same team then...

Jul 29, 2026
Bloating & IBS

How much thiamine per day: the RDA, the study doses, and the gap between them

The short answer The RDA is 1.2 mg a day for men and 1.1 mg for women, and most Americans already take in several...

Jul 29, 2026
Bloating & IBS

Does magnesium help bloating? The honest answer

The short answer No human trial has ever measured bloating as an endpoint for magnesium, in any form. Not one. The real evidence is...

Jul 29, 2026
Bloating & IBS

When to take magnesium glycinate: the timing advice online is mostly invented

The short answer There is no human evidence that time of day changes how much magnesium you absorb. Not for glycinate, not for any...

Jul 29, 2026
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Choosing a Stack

Magnesium glycinate side effects: what is real, what is dose, what is the wrong form

The short answer The common side effect is loose stools and cramping, and it is dose-driven, not form-specific. Magnesium you fail to absorb stays...

Jul 29, 2026
Choosing a Stack

Magnesium L-threonate vs glycinate: what the human trials actually show

The short answer If the goal is correcting a magnesium shortfall, glycinate wins. It delivers roughly twice the elemental magnesium per gram of material,...

Jul 29, 2026
Nausea and Vomiting

Why hot showers help nausea, and why nobody can prove it yet

The short answer Nobody knows. The relief is real and reproducible, and every proposed explanation is still a hypothesis. The most popular one, heat...

Jul 29, 2026
Vitamins and Supplements

Benfotiamine and inflammation: what the research shows, and what it doesn't

The short versionBenfotiamine, a fat-soluble form of vitamin B1, calms inflammatory signaling in cell and animal studies. Human evidence is limited and mixed: one...

Jul 22, 2026
Vitamins and Supplements

Starting a lipid-soluble vitamin B1? Here is what to expect

The short versionLipid-soluble forms of vitamin B1 like benfotiamine and allithiamine are well tolerated in long studies, with side effects similar to placebo. A...

Jul 22, 2026
Research and Diagnostics

Probiotics for kids' stomachaches: what the newest evidence really shows

The short versionFor children with recurring functional abdominal pain, probiotics show at best a small, low-certainty benefit limited to two specific strains, and never...

Jul 22, 2026
Research and Diagnostics

GLP-1 drugs and vitamin B1: what the Wernicke's reports actually mean

The short versionGLP-1 medications blunt appetite and can cause vomiting, and a small number of case reports link that to thiamine (vitamin B1) deficiency...

Jul 22, 2026
IBS and Bowel Habits

Magnesium for constipation-predominant IBS: what the evidence supports

The short version Certain magnesium salts work as osmotic laxatives, pulling water into the bowel to soften and move stool. Magnesium oxide has the...

Jul 19, 2026
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