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Gut-brain in plain English.

Research, mechanism, and small daily decisions. Written by an ER physician for the cluster of people the textbooks keep missing.

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Stress and Sleep

The 3 p.m. crash is not a sleep problem

The short versionThe daily afternoon crash usually is not about sleep quantity. It tracks with fuel access in the nervous system: B1 and magnesium...

Jul 19, 2026
Bloating and IBS

Brain fog after eating: why meals slow your mind

The short versionPost-meal fog is a gut-brain signaling event, not a character flaw. Blood flow shifts, signaling runs through one underfueled wire, and the...

Jul 19, 2026
Blog

What an ER doctor learned about chronic gut symptoms

From the Founder What an ER doctor learned about chronic gut symptoms July 10, 2026·Rick Pescatore, DO Notes from a lot of late shifts,...

Jul 10, 2026
Blog

Functional dyspepsia: why the stomach won't settle

Conditions Functional dyspepsia: why the stomach won't settle July 10, 2026·Rick Pescatore, DO TL;DR Functional dyspepsia is chronic upper-belly discomfort, early fullness, heaviness after...

Jul 10, 2026
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Blog

Rome V and disorders of gut-brain interaction: what changed

Clinical Evidence Rome V and disorders of gut-brain interaction: what changed July 10, 2026·Rick Pescatore, DO TL;DR If a doctor has ever called your...

Jul 10, 2026
Blog

Cannabinoid hyperemesis syndrome: what the evidence says

Clinical Evidence Cannabinoid hyperemesis syndrome: what the evidence says July 10, 2026·Rick Pescatore, DO TL;DR Cannabinoid hyperemesis syndrome is a pattern of severe, recurring...

Jul 10, 2026
Blog

What the gut-brain axis actually is

Gut-Brain Science What the gut-brain axis actually is July 10, 2026·Rick Pescatore, DO TL;DR Your gut and your brain are physically wired together, through...

Jul 10, 2026
Blog

Thiamine and the gut-brain connection: what vitamin B1 actually does

Vitamins and Supplements Thiamine and the gut-brain connection: what vitamin B1 actually does July 8, 2026·Rick Pescatore, DO Reading because this is your pattern?MGB+...

Jul 8, 2026
Vitamins and Supplements

Magnesium glycinate vs magnesium citrate: pick by what you want it to do.

The word magnesium on a supplement label is doing too much work. Magnesium is the element. The form it is bound to changes almost...

May 20, 2026
Reflux and Dyspepsia

Gastroparesis vs functional dyspepsia: the test that separates them.

Two patients walk into a GI clinic. Both describe early fullness, upper abdominal pain, nausea, and the feeling that food sits like a brick....

May 20, 2026
Reflux and Dyspepsia

Functional dyspepsia vs GERD: how to tell them apart.

Most people who feel post-meal burning, fullness, or upper-abdominal pain are told they probably have reflux. Half the time, that label is right. The...

May 20, 2026
Research and Diagnostics

Rome V vs Rome IV: what actually changed in 2026.

Every six to ten years, the Rome Foundation, the international body of gastroenterologists who define and classify what used to be called functional GI...

May 20, 2026
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